Early Predictive Marker for Kidney Disease
Chronic Kidney Disease (CKD) is a worldwide problem that carries a substantial risk for cardiovascular morbidity and death. Early kidney disease has no symptoms. Current guidelines define CKD as kidney damage or Glomerular Filtration Rate (GFR) less than 60mL/min per 1.73 m2 for 3 months or more, regardless of cause. GFR is the most frequently used criteria in the assessment of renal function.
Serum creatinine is the most commonly used marker for estimation of GFR. However, creatinine is significantly affected by several factors such as muscle mass, diet, gender, age and tubular secretion.
This leads to the study of Cystatin C as a predictive marker for CKD. Cystatin C is a relatively small protein that is produced throughout the body by all cells that contain a nucleus and is found in a variety of body fluids, including the blood. It is produced and filtered from the blood by the kidneys and broken down at a constant rate. This test measures the amount of Cystatin C in blood to evaluate kidney function.